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Pre-clinical research from the University of Guelph found that a cannabis compound that does not have the “high” effect can help to alleviate nausea in chemotherapy patients. 

The research was published in eNeuro this week and is the first to show that alternate cannabis compounds can be just as, or more effective than typical nausea drugs. 

The researchers studied rats to determine the cause of and treatment of nausea in the brain. They found that nausea-inducing treatments elevates serotonin in the region of the brain called the interceptive insular cortex. Cannabinoid acts to prevent its release, therefore stifling nausea. 

The cannabinoid that was best found to stifle the nausea in the trial was the natural cannabinoid 2-AG. Professor Linda Parker points out “we can trick the brain into making more 2-AG by giving drugs that prevent its breakdown by enzymes in this region of the brain”. 

Source: https://kitchener.ctvnews.ca/guelph-study-finds-cannabis-compound-can-curb-nausea-during-chemo-1.4036632

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